反应详情

1-[1-Triphenylmethyl-1H-imidazol-4-yl]-6-cyclohexyl-3-hexyne (6.8 g, 0.014 mol) was dissolved in dry ethyl acetate (100 ml). Lindlar catalyst (5%, 1.8 g Pd on CaCO3 poisoned with lead) and 15 mgs of quinoline were added. H2 was added to the reaction flask via a balloon. The reaction flask was evacuated and then refilled with H2 gas from the balloon 3 times. The reaction was left to stir at room temperature under the presence of H2 (1 atm) for 48 hours. The H2 gas was removed and the reaction mixture filtered through a pad of celite with ethyl acetate, the ethyl acetate was removed in vacuo to afford 6.75 g of 1-[1-triphenylmethyl-1H-imidazol-4-yl]-6-cyclohexyl-cis-3-hexene.

1. additionH2 was added to the reaction flask via a balloon
2. customThe reaction flask was evacuated
3. additionrefilled with H2 gas from the balloon 3 times
4. waitThe reaction was left
5. customThe H2 gas was removed
6. filtrationthe reaction mixture filtered through a pad of celite with ethyl acetate
7. customthe ethyl acetate was removed in vacuo