1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one → HCID 18428530, compound

HRID 1279529Notes

Reaction equation

HRID 1279529 reaction equation
[NH:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH2:5][CH2:4][CH2:3][C:2]1=[O:12].F[B-](F)(F)F.[CH3:18][O+](C)C>>[CH3:18][O:12][C:2]1[CH2:3][CH2:4][CH2:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N:1]=1

Participants

3

Reactant 2

HCID 2485801,3,4,5-Tetrahydro-2H-1-benzazepin-2-oneHCID 2735153Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1)

Product 1

HCID 18428530HCID 18428530, compound

Procedure

A sample of the title compound of EXAMPLE 165 (3.2 g, 20.0 mmol) was reacted with trimethyloxonium tetrafluoroborate (4.4 g, 30.0 mmol) by the method of EXAMPLE 26 to yield, after chromatography, 2.5 g (73%) of the title material.

Workup

  1. customto yield

Sources & evidence

ORD record
ord-6f62db7a5912451082df819a0bde9a3d
Source dataset
uspto-grants-2002_09
Patent number
US06448286B1

Reaction notes

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