Acetic Anhydride → N-(1,1-dimethylethyl)-N-(3,3,3-trichloro-2-hydroxypropyl)acetamide

HRID 127953Notes

Reaction equation

HRID 127953 reaction equation
[CH3:1][C:2]([NH:5][CH2:6][CH:7]([OH:12])[C:8]([Cl:11])([Cl:10])[Cl:9])([CH3:4])[CH3:3].[C:13](OC(=O)C)(=[O:15])[CH3:14]>ClCCl>[CH3:4][C:2]([N:5]([CH2:6][CH:7]([OH:12])[C:8]([Cl:11])([Cl:10])[Cl:9])[C:13](=[O:15])[CH3:14])([CH3:1])[CH3:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 234710203-(Tert-butylamino)-1,1,1-trichloropropan-2-ol

Product 1

HCID 23471021N-(1,1-dimethylethyl)-N-(3,3,3-trichloro-2-hydroxypropyl)acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction of 3-(1,1-dimethylethylamino)-1,1,1-trichloro-2-propanol with acetic anhydride takes place at about -70° to +70° C. in a solvent such as dichloromethane to produce the N-(1,1-dimethylethyl)-N-(3,3,3-trichloro-2-hydroxypropyl)acetamide of this invention.

Workup

  1. customat about -70° to +70° C.

Sources & evidence

ORD record
ord-b464da8834294a5189355b6d91486acd
Source dataset
uspto-grants-1981_03
Patent number
US04258060

Reaction notes

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