4-Methyl-5-[3-[(tetrahydropyran-2-yl)oxy]propyl]pyrrolidin-2-one → 5-(3-Hydroxypropyl)-4-methylpyrrolidin-2-one

HRID 1279546Notes

Reaction equation

HRID 1279546 reaction equation
[CH3:1][CH:2]1[CH:6]([CH2:7][CH2:8][CH2:9][O:10]C2CCCCO2)[NH:5][C:4](=[O:17])[CH2:3]1>C(O)(=O)C.C1COCC1.O>[OH:10][CH2:9][CH2:8][CH2:7][CH:6]1[NH:5][C:4](=[O:17])[CH2:3][CH:2]1[CH3:1]

Participants

3

Reactant 1

HCID 184285414-Methyl-5-[3-[(tetrahydropyran-2-yl)oxy]propyl]pyrrolidin-2-one

Product 1

HCID 184285635-(3-Hydroxypropyl)-4-methylpyrrolidin-2-one

Reagents, catalysts & solvents 1

HCID 21877175AcOH THF waterSolvent

Procedure

A mixture of the title compound of EXAMPLE 234 is treated with acetic acid:THF:water (4:2:1), and concentrated. The resulting material is purified by column chromatography to yield the title material.

Workup

  1. concentrationconcentrated
  2. customThe resulting material is purified by column chromatography

Sources & evidence

ORD record
ord-4650290ff8294fd889b38d8670fb4b5b
Source dataset
uspto-grants-2002_09
Patent number
US06448286B1

Reaction notes

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