2-Amino-6-(trifluoromethyl)pyridine → HCID 178476688, compound

HRID 1279576Notes

Reaction equation

HRID 1279576 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].N=C1CC(C)CCN1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[N:15]=1>>[C:1]([OH:4])(=[O:3])[CH3:2].[NH:13]=[C:14]1[CH2:19][CH2:18][CH2:17][CH:16]([C:20]([F:22])([F:21])[F:23])[NH:15]1

Participants

3

Reactant 2

HCID 8210242-Amino-6-(trifluoromethyl)pyridineHCID 1784758702-Imino-4-methylpiperidine acetate

Product 1

HCID 178476688HCID 178476688, compound

Procedure

The method of preparation of 2-imino-4-methylpiperidine acetate was used to convert 2-amino-6-(trifluoromethyl)pyridine to the title compound. Product was crystallized from EtOAc to give a white solid. The analysis of the product was found to be consistent with the proposed structure. MH+=167; 1H NMR (D2O): δ4.20-4.00 (m, 1H); 2.60-2.50 (m, 2H); 2.05-1.50 (m, 4H); 1.80 (s, 3H).

Sources & evidence

ORD record
ord-3361b26008964971b3fb545f6dfb199c
Source dataset
uspto-grants-2002_09
Patent number
US06448286B1

Reaction notes

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