4-Propylpyridin-2-amine → HCID 178476207, compound

HRID 1279577Notes

Reaction equation

HRID 1279577 reaction equation
[C:1]([OH:4])(=[O:3])[CH3:2].N=C1CC(C)CCN1.[NH2:13][C:14]1[CH:19]=[C:18]([CH2:20][CH2:21][CH3:22])[CH:17]=[CH:16][N:15]=1>>[C:1]([OH:4])(=[O:3])[CH3:2].[NH:13]=[C:14]1[CH2:19][CH:18]([CH2:20][CH2:21][CH3:22])[CH2:17][CH2:16][NH:15]1

Participants

3

Reactant 2

HCID 70225944-Propylpyridin-2-amineHCID 1784758702-Imino-4-methylpiperidine acetate

Product 1

HCID 178476207HCID 178476207, compound

Procedure

The method of preparation of 2-imino-4-methylpiperidine acetate was used to convert 2-amino-4-(n-propyl)pyridine to the title compound except platinum oxide was used as the catalyst. Product was triturated with EtOAc to give a white solid. The analysis of the product was found to be consistent with the proposed structure. MH+141; 1H NMR (D2O): δ63.35-3.05 (m, 2H); 2.60-2.40 (m, 1H); 2.15-2.00 (m, 1H); 1.80-1.60 (m, 2H); 1.78 (s, 3H); 1.35-1.05 (m, 5H); 0.75-0.65 (m, 3H).

Sources & evidence

ORD record
ord-32d58ddcce4f444396d2c71eb8286903
Source dataset
uspto-grants-2002_09
Patent number
US06448286B1

Reaction notes

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