Hydrochloric Acid → 138964-58-6

HRID 1279589Notes

Reaction equation

HRID 1279589 reaction equation
[C:1]1([S:7]([NH:10][C:11]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:12]=2[C:13]([O:15]C)=[O:14])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Cl>C1COCC1.CO>[C:1]1([S:7]([NH:10][C:11]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:12]=2[C:13]([OH:15])=[O:14])(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12017646HCID 12017646, compound

Product 1

HCID 12017647138964-58-6Yield 100.1%

Reagents, catalysts & solvents 1

HCID 21899815MeOH tetrahydrofuranSolvent

Procedure

To a solution of methyl 2-phenylsulfonylamino-5-chlorobenzoate (600 mg; prepared in Reference Example 2.) in the mixture of THF-MeOH (6 ml+3 ml), 2N NaOH solution (2 ml) was added. The mixture was stirred for 2 days. To the reaction mixture, 1N HCl (4.5 ml) was added. The mixture was extracted with ethyl acetate. The organic layer was washed and dried over to give the title compound (575 mg) having the following physical data.

Workup

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed
  4. customdried over

Sources & evidence

ORD record
ord-4030f577b20044dbac662e6e86204414
Source dataset
uspto-grants-2002_09
Patent number
US06448290B1

Reaction notes

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