HCID 69918591, compound → HCID 12017658, compound

HRID 1279594Notes

Reaction equation

HRID 1279594 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[CH:19]=[CH:20][C:21]2[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[H][H]>C1COCC1.O.[Pt]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:13]=2[CH2:19][CH2:20][C:21]2[CH:22]=[CH:23][C:24]([C:25]([OH:27])=[O:26])=[CH:28][CH:29]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 69918591HCID 69918591, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 12017658HCID 12017658, compoundYield 84.8%

Reagents, catalysts & solvents 2

HCID 86587499Platinum oxide monohydrateCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 4-[2-[2-(4-chlorophenyl)sulfonylamino-5-chlorophenyl]vinyl]benzoic acid (54 mg; prepared in Example 5.) in THF (4 ml), platinum oxide hydrate (3 mg) was added. The mixture was stirred for 2 hours at room temperature in a stream of hydrogen. The reaction mixture was filtered and the filtrate was concentrated under the reduced pressure. To the residue, methylene chloride was added. The mixture was stirred. The precipitate was collected by filter to give the title compound (46 mg) having the following physical data.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under the reduced pressure
  3. additionTo the residue, methylene chloride was added
  4. customThe precipitate was collected
  5. filtrationby filter

Sources & evidence

ORD record
ord-71ae81d12a8743938356fcf11f04ec7f
Source dataset
uspto-grants-2002_09
Patent number
US06448290B1

Reaction notes

Loading…