Hydrochloric Acid → HCID 86615961, compound

HRID 12796Notes

Reaction equation

HRID 12796 reaction equation
[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][C@H:21]3[C@:19]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)([CH2:20]3)[CH2:18]2)[CH:13]=1.[ClH:35]>O1CCOCC1>[ClH:35].[ClH:35].[F:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[C:8]1[C:9](=[O:34])[NH:10][C:11](=[O:33])[N:12]([CH2:14][CH2:15][CH2:16][N:17]2[CH2:22][C@H:21]3[C@:19]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][CH:24]=4)([CH2:20]3)[CH2:18]2)[CH:13]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 247596585-(3-fluoro-4-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 86615961HCID 86615961, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

5-(3-fluoro-4-pyridinyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was dissolved in dioxane and treated with 4N HCl in dioxane (2 eq), to give the title compound as a white powder.

Sources & evidence

ORD record
ord-813dcb257d3544dcaee9ba55bdbd65db
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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