Acetic Anhydride → HCID 22672035, compound

HRID 1279619Notes

Reaction equation

HRID 1279619 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])=[C:7]([O:21][CH3:22])[CH:6]=1)([OH:4])[CH3:3].[C:23](OC(=O)C)(=[O:25])[CH3:24]>C(Cl)Cl.C(N(CC)CC)C>[CH3:3][C:2]([C:5]1[CH:10]=[CH:9][C:8]([N:11]([S:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)(=[O:14])=[O:13])[C:23](=[O:25])[CH3:24])=[C:7]([O:21][CH3:22])[CH:6]=1)([OH:4])[CH3:1]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 22672167HCID 22672167, compound

Product 1

HCID 22672035HCID 22672035, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

To a solution of 1-methyl-1-(4-phenylsulfonylamino-3-methoxyphenyl)ethanol (2.65 g; prepared in Reference Example 38.) in methylene chloride (15 ml), acetic anhydride (3.05 ml) and triethylamine (4.60 ml) were added. The mixture was stirred overnight at room temperature. The solvent was distilled off. The residue was purified on silica gel column chromatography (hexane:AcOEt=3 4) to give the title compound (2.33 g) having the following physical data.

Workup

  1. distillationThe solvent was distilled off
  2. customThe residue was purified on silica gel column chromatography (hexane:AcOEt=3 4)

Sources & evidence

ORD record
ord-7d4fd1b314164eb282ccb996d236fde0
Source dataset
uspto-grants-2002_09
Patent number
US06448290B1

Reaction notes

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