反应详情

温度

0 °C

A solution of ethyl 2-[(5-{(1R)-4-cyclohexyl-1 -[2-(hydroxyamino)-2-oxoethyl]butyl}-1,2,4-oxadiazol-3-yl)methoxy]propanoate (Example 51) (184 mg, 0.45 mmol) in 1,4-dioxan (4 ml) and water (2 ml) was cooled to 0° C. and treated with lithium hydroxide monohydrate (2 mg, 0.48 mmol) and stirred at 0° C. for 2 hours. The solvent was partially removed under reduced pressure and diluted with water and washed with diethylether (×2). The aqueous layer was acidified to pH 1 with hydrochloric acid (2M) and washed with ethyl acetate (×2). The combined organic layers were washed with brine, dries over anhydrous sodium sulphate, filtered and the solvent was removed under reduced pressure to afford the title compound as a colourless oil (160 mg).

1. customThe solvent was partially removed under reduced pressure
2. additiondiluted with water
3. washwashed with diethylether (×2)
4. washwashed with ethyl acetate (×2)
5. washThe combined organic layers were washed with brine, dries over anhydrous sodium sulphate
6. filtrationfiltered
7. customthe solvent was removed under reduced pressure