反应详情

温度

60 °C

A solution of ethyl 5-{(1R)-1 -[2-(tert-butoxy)2-oxoethyl]4-cyclohexylbutyl}-1,2,4-oxadiazole-3-carboxylate (Preparation 3) (300 mg, 0.76 mmol) in ethanol (4 ml) was treated dropwise with pyrrolidine (0.63 ml, 7.60 mmol) and the resulting solution was heated at 60° C. for 9 hours. The solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel eluting with dichloromethane:ethyl acetate (4:1) to afford the title compound as a pale yellow oil (360 mg).

1. customThe solvent was removed under reduced pressure
2. customthe residue was purified by column chromatography on silica gel eluting with dichloromethane:ethyl acetate (4:1)