反应详情

温度

60 °C

A solution of ethyl 5-{(1R)-1-[2-(tert-butoxy)-2-oxoethyl]4-cyclohexylbutyl}-1,2,4-oxadiazole-3-carboxylate (Preparation 3) (300 mg, 0.76 mmol) in ethanol (4 ml) was treated with 1-methylpiperazine (0.84 ml, 7.60 mmol) and the resulting mixture was heated at 60° C. under a nitrogen atmosphere for 16 hours. The mixture was cooled and the solvent removed under reduced pressure. The residue was purified by column chromatography on silica gel eluting with a gradient system of dichloromethane:methanol (98:2) gradually changing to dichloromethane methanol (95:5) to afford the title compound (312 mg).

1. temperatureThe mixture was cooled
2. customthe solvent removed under reduced pressure
3. customThe residue was purified by column chromatography on silica gel eluting with a gradient system of dichloromethane:methanol (98:2)