HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-[2,4-dioxo-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]-2-pyridinecarbonitrile dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 24758085 | HCID 24758085 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-[2,4-dioxo-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]-2-pyridinecarbonitrile dihydrochloride | HCID 68691280 | 29% |
Reaction Steps
6-[2,4-dioxo-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]-2-pyridinecarbonitrile was dissolved in dioxane and treated with 4N HCl in dioxane (2 eq), to give 68 mg of the title compound as a white powder (29% yield)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727988B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-f0270e33ab6542d9bb50f8a60df69476 |
| Source note | uspto-grants-2010_06 |