HRID12799

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：N#Cc1cccc(-c2cn(CCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)n1

HCID24758085

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.N#Cc1cccc(-c2cn(CCCN3C[C@@H]4C[C@]4(c4ccc(C(F)(F)F)cc4)C3)c(=O)[nH]c2=O)n1

HCID68691280

未命名化合物

收率 29%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

6-[2,4-dioxo-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-1,2,3,4-tetrahydro-5-pyrimidinyl]-2-pyridinecarbonitrile was dissolved in dioxane and treated with 4N HCl in dioxane (2 eq), to give 68 mg of the title compound as a white powder (29% yield)