HCID 23433656, compound → HCID 23433458, compound

HRID 1279937Notes

Reaction equation

HRID 1279937 reaction equation
[NH2:1][C:2]1[CH:14]=[CH:13][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[F:15])[CH2:5][C:4]=2[CH:3]=1>CCCCCC.CCOC(C)=O>[F:15][C:10]1[C:11]2[C:12]3=[CH:13][C:14]4[C:2](=[CH:3][C:4]3=[CH:5][C:6]=2[CH:7]=[CH:8][CH:9]=1)[NH:1][C:4]([CH3:5])([CH3:12])[CH2:3][C:2]=4[CH3:14]

Participants

3

Reactant 1

HCID 23433656HCID 23433656, compound

Product 1

HCID 23433458HCID 23433458, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

This compound was prepared according to General Method 3 (EXAMPLE 16) from 2-amino-5-fluorofluorene (structure 15, where R2, R4-6=H, R3=F, X=CH2) (360 mg, 1.72 mmol) to 125 mg (26%) of Compound 126 as a light brown solid. Data for Compound 126: Rf=0.63 (silca gel, hexane/EtOAc, 3:1); 1H NMR (400 MHz, acetone-d6): 7.55 (s, 1H), 7.25 (d, J=7.3, 1H), 7.12 (m, 1H), 7.02 (d, J=10, 10, 1H) 6.73 (s, 1H), 5.39 (s, 1H), 3.81 (s, 2H), 2.87 (s, 3H), 1.28 (s, 6H).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-31cf75aaa46b46f5a795123b5e88ed47
Source dataset
uspto-grants-2002_09
Patent number
US06448405B1

Reaction notes

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