Ammonium Hydroxide → HCID 9899303, compound

HRID 1280081Notes

Reaction equation

HRID 1280081 reaction equation
Cl.CO[C:4](=[O:18])[C@H:5]([CH2:7][C:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([OH:17])[CH:15]=2)[NH:10][CH:9]=1)[NH2:6].[OH-].[NH4+:20]>>[OH:17][C:14]1[CH:15]=[C:16]2[C:11]([NH:10][CH:9]=[C:8]2[CH2:7][C@@H:5]([C:4]([NH2:20])=[O:18])[NH2:6])=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 24802218methyl (2S)-2-amino-3-(5-hydroxy-1H-indol-3-yl)propanoate hydrochloride

Product 1

HCID 9899303HCID 9899303, compound

Procedure

(S)-5-Hydroxytryptophan methyl ester hydrochloride (0.247 g, 0.91 mmol) was stirred overnight at room temperature in ammonium hydroxide (10 mL). After removal of volatiles under vacuum, the title compound of example 44 was obtained as a dark solid.

Workup

  1. customAfter removal of volatiles under vacuum

Sources & evidence

ORD record
ord-b30ac39db0c6490d81b514204032cb63
Source dataset
uspto-grants-2002_09
Patent number
US06448281B1

Reaction notes

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