2-Amino-2-methyl-1-propanol → HCID 491198, compound

HRID 1280097Notes

Reaction equation

HRID 1280097 reaction equation
CN(C)CCN[C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7].[NH2:44][C:45]([CH3:49])([CH3:48])[CH2:46][OH:47]>>[OH:47][CH2:46][C:45]([NH:44][C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7])([CH3:49])[CH3:48]

Participants

3

Reactant 2

HCID 118072-Amino-2-methyl-1-propanolHCID 491192HCID 491192, compound

Product 1

HCID 491198HCID 491198, compound

Procedure

The carboxylic acid of example 133 was coupled to 2-amino-2-methyl-1-propanol under standard TBTU conditions to yield the title compound of example 139.

Sources & evidence

ORD record
ord-4c6a4a6835b14e1e9e84dba81c8d55d9
Source dataset
uspto-grants-2002_09
Patent number
US06448281B1

Reaction notes

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