3-Amino-1,2-propanediol → HCID 491199, compound

HRID 1280098Notes

Reaction equation

HRID 1280098 reaction equation
CN(C)CCN[C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7].[NH2:44][CH2:45][CH:46]([OH:49])[CH2:47][OH:48]>>[OH:49][CH:46]([CH2:47][OH:48])[CH2:45][NH:44][C:6]([C@@H:8]([NH:20][C:21]([C:23]1[CH:42]=[CH:41][C:26]2[N:27]([CH:35]3[CH2:40][CH2:39][CH2:38][CH2:37][CH2:36]3)[C:28]([C:30]3[CH:34]=[CH:33][O:32][CH:31]=3)=[N:29][C:25]=2[CH:24]=1)=[O:22])[CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[C:16]([OH:19])[CH:17]=2)[NH:12][CH:11]=1)=[O:7]

Participants

3

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 491192HCID 491192, compound

Product 1

HCID 491199HCID 491199, compound

Procedure

The carboxylic acid of example 133 was coupled to racemic 3-amino-1,2-propanediol under standard TBTU conditions to yield the title compound of example 140.

Sources & evidence

ORD record
ord-daeb0a2f586945c2a9e872d811b42bd3
Source dataset
uspto-grants-2002_09
Patent number
US06448281B1

Reaction notes

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