1,3-Propanediamine → HCID 19763488, compound

HRID 128010Notes

Reaction equation

HRID 128010 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][NH2:5].CO[C:8](=O)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>>[C:9]1([CH:8]2[NH:5][CH2:4][CH:3]=[CH:2][NH:1]2)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 4281,3-PropanediamineHCID 7150Methyl Benzoate

Product 1

HCID 19763488HCID 19763488, compoundYield 79%

Procedure

With 185 g 1,3-diaminopropane, 136 g benzoic acid methyl ester were reacted under pressure at 200° C. in the reactor. After 3 hours, the excess of diamine was distilled off, and the 2-phenyl-tetrahydropyrimidine was isolated in a 79% yield. Boiling point 165° C./1 mm; melting point=86°-87° C.

Workup

  1. distillationthe excess of diamine was distilled off

Sources & evidence

ORD record
ord-2f5adba5db884ee380f7cb8c8031258e
Source dataset
uspto-grants-1981_03
Patent number
US04258186

Reaction notes

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