Hydrochloric Acid → HCID 18429266, compound

HRID 1280128Notes

Reaction equation

HRID 1280128 reaction equation
C([O:4][CH:5]([CH3:38])[C:6]([N:8]([CH2:32][CH2:33][O:34]C(=O)C)[C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([O:25]C(=O)C)[CH3:24])[C:19]=1[I:20])CCC([O-])=O)=[O:7])(=O)C.[OH-:39].[Na+].Cl.[CH3:42]O>O>[OH:4][CH:5]([CH3:38])[C:6]([N:8]([CH2:32][CH2:33][OH:34])[C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([OH:25])[CH3:24])[C:19]=1[I:20])[CH2:42][OH:39])=[O:7]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 18429223HCID 18429223, compound

Product 1

HCID 18429266HCID 18429266, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N,N′-Bis(2-acetoxypropionyl)-N-(2-acetoxyethyl)-3,5-diamino-2,4,6-triiodobenzylacetate (120 mg, 0.14 mmol) was dissolved in a mixture of water (7 ml) and methanol (7 ml) and pH was adjusted to 12 using an 1 M aqueous solution of NaOH. The mixture was stirred for 2 h, pH was adjusted to 7 with aqueous HCl and the solvents were evaporated. The product was purified by preparative HPLC. Yield: 70 mg (72%).

Workup

  1. customthe solvents were evaporated
  2. customThe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-9d86a49388674d5da23d53e64f254727
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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