Potassium Carbonate → HCID 18429271, compound

HRID 1280155Notes

Reaction equation

HRID 1280155 reaction equation
CC1(C)[O:6][CH:5]([C:7]([NH:9][C:10]2[C:11]([I:37])=[C:12]([CH2:32][O:33]C(=O)C)[C:13]([I:31])=[C:14]([C:29]=2[I:30])[C:15]([NH:17][CH2:18][CH:19]([O:25]C(=O)C)[CH2:20][O:21]C(=O)C)=[O:16])=[O:8])[CH2:4][O:3]1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:6][CH:5]([CH2:4][OH:3])[C:7]([NH:9][C:10]1[C:11]([I:37])=[C:12]([CH2:32][OH:33])[C:13]([I:31])=[C:14]([C:29]=1[I:30])[C:15]([NH:17][CH2:18][CH:19]([OH:25])[CH2:20][OH:21])=[O:16])=[O:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18429160HCID 18429160, compound

Product 1

HCID 18429271HCID 18429271, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2,2-Dimethyl-1,3-dioxolane-4-carbamido)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (0.80 g, 9.16 mmol) was dissolved in methanol (7 ml) and potassium carbonate (0.17 g, 12.3 mmol) was added. The mixture was stirred at room temperature for 17 h. The mixture was filtered and pH of the filtrate was adjusted to 1 using aqueous SM hydrochloric acid, and the mixture was stirred for further 5 h at room temperature. The reaction mixture was then evaporated to a solid residue, which was purified by preparative HPLC. Yield: 0.41 g (49%) of a white freeze dried product.

Workup

  1. filtrationThe mixture was filtered
  2. stirringthe mixture was stirred for further 5 h at room temperature
  3. customThe reaction mixture was then evaporated to a solid residue, which
  4. customwas purified by preparative HPLC

Sources & evidence

ORD record
ord-331c4a9f03484cc490ec6f3b1ca51831
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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