HCID 18429135, compound → HCID 18429237, compound

HRID 1280166Notes

Reaction equation

HRID 1280166 reaction equation
[NH2:1][C:2]1[C:3]([I:20])=[C:4]([CH2:15][O:16][C:17](=[O:19])[CH3:18])[C:5]([I:14])=[C:6]([CH2:9][O:10][C:11](=[O:13])[CH3:12])[C:7]=1[I:8].[C:21]([O:24][CH:25]([CH:29]([O:35][C:36](=[O:38])[CH3:37])[CH2:30][O:31][C:32](=[O:34])[CH3:33])[C:26](Cl)=[O:27])(=[O:23])[CH3:22]>CC(N(C)C)=O>[C:21]([O:24][CH:25]([CH:29]([O:35][C:36](=[O:38])[CH3:37])[CH2:30][O:31][C:32](=[O:34])[CH3:33])[C:26]([NH:1][C:2]1[C:7]([I:8])=[C:6]([CH2:9][O:10][C:11](=[O:13])[CH3:12])[C:5]([I:14])=[C:4]([CH2:15][O:16][C:17](=[O:19])[CH3:18])[C:3]=1[I:20])=[O:27])(=[O:23])[CH3:22]

Participants

4

Reactant 2

HCID 18429135HCID 18429135, compoundHCID 18429226HCID 18429226, compound

Product 1

HCID 18429237HCID 18429237, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

5-Amino-2,4,6-triiodo-1,3-di-(acetoxymethyl)benzene (2.0 g, 3.25 mmol) was dissolved in dimethylacetamide (4 ml) at room temperature. 2,3,4-Triacetoxybutyryl chloride (7.4 g, 26.4 mmol) was added and the mixture was stirred for 20 h. The work up was carried out as in Example 24i. A white crystalline product 2.2 g (79%), was isolated.

Sources & evidence

ORD record
ord-3ad30884e8094a139d3c39e0f6f01baa
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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