Acetoxyacetyl chloride → HCID 86757557, compound

HRID 1280177Notes

Reaction equation

HRID 1280177 reaction equation
[NH2:1][C:2]1[C:3]([I:22])=[C:4]([CH2:11][CH:12]([O:18][C:19](=[O:21])[CH3:20])[CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:5]([I:10])=[C:6]([NH2:9])[C:7]=1[I:8].[C:23]([O:26][CH2:27][C:28](Cl)=[O:29])(=[O:25])[CH3:24]>C(Cl)Cl.C(#N)C>[C:23]([O:26][CH2:27][C:28]([NH:9][C:6]1[C:5]([I:10])=[C:4]([CH2:11][CH:12]([O:18][C:19](=[O:21])[CH3:20])[CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:3]([I:22])=[C:2]([NH:1][C:12](=[O:18])[CH2:13][O:14][C:15](=[O:17])[CH3:16])[C:7]=1[I:8])=[O:29])(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 26297Acetoxyacetyl chlorideHCID 18429197HCID 18429197, compound

Product 1

HCID 86757557HCID 86757557, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 21877088Acetonitrile methylene chlorideSolvent

Procedure

The product in Example 64e, 3,5-diamino-2,4,6-triiodo-(2,3-diacetoxypropyl)benzene was acylated using acetoxyacetyl chloride according to the general procedure in Example 24i. After chromatography on silica gel using methylene chloride/acetonitrile (3/1) as the eluent the product was isolated in 64% yield.

Workup

  1. customwas isolated in 64% yield

Sources & evidence

ORD record
ord-430d5a88f1164a9080d1914ef5773612
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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