Lithium Bromide → HCID 18429216, compound

HRID 1280180Notes

Reaction equation

HRID 1280180 reaction equation
[C:1]([O:4][CH:5]([CH:9]([O:15][C:16](=[O:18])[CH3:17])[CH2:10][O:11][C:12](=[O:14])[CH3:13])[C:6](Cl)=[O:7])(=[O:3])[CH3:2].[Br-:19].[Li+]>C(Cl)Cl>[C:1]([O:4][CH:5]([CH:9]([O:15][C:16](=[O:18])[CH3:17])[CH2:10][O:11][C:12](=[O:14])[CH3:13])[C:6]([Br:19])=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 82050Lithium BromideHCID 18429135HCID 18429135, compound

Product 1

HCID 18429216HCID 18429216, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2,3,4-Triacetoxybutanoyl chloride (39.9 g, 0.142 mol), prepared according to the liteature procedure Glattfeld, J. and Kribben, B., J.Am. Chem. Soc. 61 (1939) 1720) was mixed with lithium bromide (30.9 g, 0.356 mol) in methylene chloride (400 ml) and stirred at ambient temperature for 24 h. The mixture was filtered, the solid was washed with additional methylene chloride (50 ml) and the filtrate was evaporated at ambient temperature to give 45 g (97%) of the crude product as an oil.

Workup

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with additional methylene chloride (50 ml)
  3. customthe filtrate was evaporated at ambient temperature

Sources & evidence

ORD record
ord-b21ca41a08444867ae0786fa2bd921f8
Source dataset
uspto-grants-2002_09
Patent number
US06448442B1

Reaction notes

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