Ethanol → HCID 23471632, compound

HRID 128035Notes

Reaction equation

HRID 128035 reaction equation
[C:1]([C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[NH:16][C:17]([NH:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:18])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:26](O)[CH3:27]>>[Cl:15][C:13]1[CH:14]=[C:9]2[C:10](=[CH:11][CH:12]=1)[NH:16][C:17](=[O:18])[N:19]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:1]2([O:8][CH2:26][CH3:27])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 44239461-(2-Benzoyl-4-chlorophenyl)-3-phenylurea

Product 1

HCID 23471632HCID 23471632, compoundYield 88%

Procedure

A solution of 10.0 g (0.285 mole) of 1-(2-benzoyl-4-chlorophenyl)-3-phenylurea in 50 ml ethanol was refluxed for 18 hr, and then cooled. The solid that formed was collected on a filter and washed with ethanol to give 9.46 g (88%) of 6-chloro-4-ethoxy-3,4-dihydro-3,4-diphenyl-2(1H)-quinazolinone as colorless crystals: mp 209°-211°. The 1H nmr spectrum shows the presence of an ethyl group in addition to aromatic hydrogens.

Workup

  1. temperaturecooled
  2. customThe solid that formed
  3. customwas collected on
  4. filtrationa filter
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-59a7f492dc314582a846cf85e1a155c4
Source dataset
uspto-grants-1981_03
Patent number
US04258187

Reaction notes

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