Hydroxyamine hydrochloride → HCID 178518621, compound

HRID 128036Notes

Reaction equation

HRID 128036 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[N:6](C1C=CC=CC=1)[C:5]2(OCC)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.Cl.N[OH:30]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[N+:6]([O-:30])=[C:5]2[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 23471632HCID 23471632, compound

Product 1

HCID 178518621HCID 178518621, compoundYield 72%

Procedure

A mixture of 3.51 g (0.0093 mole) of 6-chloro-4-ethoxy-3,4-dihydro-3,4-diphenyl-2(1H)-quinazolinone and 2.09 g (0.03 mole) of hydroxylamine hydrochloride in 50 ml alcohol was refluxed for 4 days, and then cooled. The solid that formed was collected on a filter, washed with ethanol, and dried in air to give 1.82 g (72%) of 6-chloro-4-phenyl-2(1H)-quinazolinone 3-oxide as yellow crystals, mp 267°-269°.

Workup

  1. temperaturewas refluxed for 4 days
  2. temperaturecooled
  3. customThe solid that formed
  4. customwas collected on a filter
  5. washwashed with ethanol
  6. customdried in air

Sources & evidence

ORD record
ord-9cd13496d4344bddb4cad1f40b6ebf7e
Source dataset
uspto-grants-1981_03
Patent number
US04258187

Reaction notes

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