反应详情

A mixture of 12.6 g (0.05 mole) of 2-amino-5-chlorobenzophenone and 6.55 g (0.055 mole) of phenyl isocyanate was heated on a steam-bath for 30 min., and then 250 ml ethanol and 10.43 g (0.15 mole) of hydroxylamine hydrochloride were added and mixture was refluxed for 2 days and then cooled. The solid precipitate that formed was collected on a filter, washed with ethanol, and dried in air to give 9.42 g (69%) of 6-chloro-4-phenyl-2(1H)-quinazolinone 3-oxide as yellow crystals, mp 267°-269°.

1. temperaturewas heated on a steam-bath for 30 min.
2. temperaturemixture was refluxed for 2 days
3. temperaturecooled
4. customThe solid precipitate that formed
5. customwas collected on a filter
6. washwashed with ethanol
7. customdried in air