Cvt-2738 → N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamide

HRID 1280418Notes

Reaction equation

HRID 1280418 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1.[CH3:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:17]=1[NH:23][C:24](=[O:32])[CH2:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>C(O)C>[CH3:22][C:18]1[CH:19]=[CH:20][CH:21]=[C:16]([CH3:15])[C:17]=1[NH:23][C:24](=[O:32])[CH2:25][N:26]1[CH2:27][CH2:28][N:29]([CH2:3][CH:2]([OH:1])[CH2:4][O:5][CH:6]2[CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:7]2)[CH2:30][CH2:31]1

Participants

4

Reactant 2

HCID 2608606Cvt-2738HCID 155803392-(Oxiran-2-ylmethoxy)indane

Product 1

HCID 10181578N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 6 (0.43 g, 2.3 mmol) in ethanol(4 ml) was added 5 (0.405 g, 1.64 mmol). The solution was heated to reflux and stirred for 24 h. Upon completion the solution was concentrated in vacuo and purified using Prep TLC (10:1, DCM:MeOH) to yield 7. Mass Spectrum (M+1)=438.36.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux
  3. concentrationUpon completion the solution was concentrated in vacuo
  4. custompurified
  5. customto yield 7

Sources & evidence

ORD record
ord-c1ea4ce8097648b5b4d19bf1deb3f259
Source dataset
uspto-grants-2002_09
Patent number
US06451798B2

Reaction notes

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