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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1280420Generated: October 27, 2026

4-(Trifluoromethyl)benzenemethanol → N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-{[4-(trifluoromethyl)phenyl]methoxy}propyl)piperazinyl]acetamide

https://huagongshe.com/reaction/1280420

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethyl)benzenemethanolHCID 67684—
ReactantN-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamideHCID 10181578—
SolventIsopropanolHCID 3776—
ProductN-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-{[4-(trifluoromethyl)phenyl]methoxy}propyl)piperazinyl]acetamideHCID 10140596—

Reaction Steps

Compound 17 was prepared in a similar manner to compound 7, substituting the commercially available 4-trifluoromethyl-benzylalcohol for 2-propanol in part C. MS (M+1)=480.37

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06451798B2
Source datasetuspto-grants-2002_09
ORD IDord-63b2184a4450438cb477a260122bbb30
Source noteuspto-grants-2002_09