4-(Trifluoromethyl)benzenemethanol → N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-{[4-(trifluoromethyl)phenyl]methoxy}propyl)piperazinyl]acetamide

HRID 1280420Notes

Reaction equation

HRID 1280420 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:31])[CH2:20][O:21][CH:22]2CC3C(=CC=CC=3)C2)[CH2:14][CH2:13]1.[F:33][C:34]([F:44])([F:43])[C:35]1[CH:42]=[CH:41][C:38](CO)=[CH:37][CH:36]=1>CC(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:31])[CH2:20][O:21][CH2:22][C:38]2[CH:41]=[CH:42][C:35]([C:34]([F:44])([F:43])[F:33])=[CH:36][CH:37]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 676844-(Trifluoromethyl)benzenemethanolHCID 10181578N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamide

Product 1

HCID 10140596N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-{[4-(trifluoromethyl)phenyl]methoxy}propyl)piperazinyl]acetamide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Compound 17 was prepared in a similar manner to compound 7, substituting the commercially available 4-trifluoromethyl-benzylalcohol for 2-propanol in part C. MS (M+1)=480.37

Sources & evidence

ORD record
ord-63b2184a4450438cb477a260122bbb30
Source dataset
uspto-grants-2002_09
Patent number
US06451798B2

Reaction notes

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