2-Methoxybenzyl alcohol → N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(2-methoxyphenyl)methoxy]propyl}piperazinyl)acetamide

HRID 1280421Notes

Reaction equation

HRID 1280421 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:31])[CH2:20][O:21][CH:22]2CC3C(=CC=CC=3)C2)[CH2:14][CH2:13]1.[CH3:33][O:34][C:35]1[CH:42]=[CH:41][CH:40]=[CH:39][C:36]=1CO>CC(O)C>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:13][CH2:14][N:15]([CH2:18][CH:19]([OH:31])[CH2:20][O:21][CH2:22][C:36]2[CH:39]=[CH:40][CH:41]=[CH:42][C:35]=2[O:34][CH3:33])[CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 691542-Methoxybenzyl alcoholHCID 10181578N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamide

Product 1

HCID 10160534N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(2-methoxyphenyl)methoxy]propyl}piperazinyl)acetamide

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Compound 18 was prepared in a similar manner to compound 7, substituting the commercially available 2-methoxy-benzylalcohol for 2-propanol in part C. MS (M+1)=442.41

Sources & evidence

ORD record
ord-3fd8055566df400abc576edd1b26f4fc
Source dataset
uspto-grants-2002_09
Patent number
US06451798B2

Reaction notes

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