(1,1'-Biphenyl)-4-methanol → HCID 10206504, compound

HRID 1280425Notes

Reaction equation

HRID 1280425 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:31])[CH2:20]OC2CC3C(=CC=CC=3)C2)[CH2:14][CH2:13]1.[C:33]1([C:39]2[CH:46]=[CH:45][C:42]([CH2:43][OH:44])=[CH:41][CH:40]=2)[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>CC(O)C>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10](=[O:32])[CH2:11][N:12]1[CH2:17][CH2:16][N:15]([CH2:18][CH:19]([OH:31])[CH2:20][O:44][CH2:43][C:42]2[CH:41]=[CH:40][C:39]([C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)=[CH:46][CH:45]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 19186(1,1'-Biphenyl)-4-methanolHCID 10181578N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-3-indan-2-yloxypropyl)piperazinyl]acetamide

Product 1

HCID 10206504HCID 10206504, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Compound 23 was prepared in a similar manner to compound 7, substituting the commercially available 4-phenylbenzylalcohol for 2-propanol in part C. MS (M+1)=488.42

Sources & evidence

ORD record
ord-ce4a3179765a4807bdb946a3c637fbbc
Source dataset
uspto-grants-2002_09
Patent number
US06451798B2

Reaction notes

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