Hydrochloric Acid → HCID 178517137, compound

HRID 1280432Notes

Reaction equation

HRID 1280432 reaction equation
[C:1]1([NH2:8])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH2:7].[C:9]1([CH2:15][C:16](=O)[C:17](O)=[O:18])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.Cl>C(O)C>[OH:18][C:17]1[C:16]([CH2:15][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[N:8][C:1]2[C:2](=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 997Phenylpyruvic acidHCID 7243O-Phenylenediamine

Product 1

HCID 178517137HCID 178517137, compoundYield 79.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

The mixture of 1,2-phenylenediamine (8.64 g), phenylpyruvic acid (13.1 g), ethanol (100 ml) and 2N hydrochloric acid (100 ml) was stirred for 1.5 hours at 50° C. The reaction mixture was cooled to room temperature. The precipitated crystals were obtained by filtration. The crystals were washed with ethanol and dried to give the title compound (15.05 g) having the following physical data.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe precipitated crystals were obtained by filtration
  3. washThe crystals were washed with ethanol
  4. customdried

Sources & evidence

ORD record
ord-3a0e6f453b6941c8ad361bcad2162132
Source dataset
uspto-grants-2002_09
Patent number
US06451796B1

Reaction notes

Loading…