5-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazole → 4,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole

HRID 1280435Notes

Reaction equation

HRID 1280435 reaction equation
[NH2:1][C:2]1[N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[N:5]=[C:4]([C:15]2[O:16][C:17]([CH2:20][OH:21])=[CH:18][CH:19]=2)[C:3]=1[N:22]=O.[H][H]>C(O)C.[Pd]>[NH2:22][C:3]1[C:4]([C:15]2[O:16][C:17]([CH2:20][OH:21])=[CH:18][CH:19]=2)=[N:5][N:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[F:14])[C:2]=1[NH2:1]

Participants

5

Reactant 2

HCID 120182125-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazoleHCID 178418361HCID 178418361, compound

Product 1

HCID 120182134,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The compound from Example 5A (8 g) is dissolved in ethanol, treated with 0.5 g of 5% strength palladium on carbon and hydrogenated for 15 minutes in a Parr apparatus at a hydrogen pressure of 2 bar. The solution is filtered off with suction through kieselguhr and used for the next batch (Rf=0.21, T1E1, SiO2).

Workup

  1. filtrationThe solution is filtered off with suction through kieselguhr

Sources & evidence

ORD record
ord-7b096c78b4aa484ea3da298ce5dd0031
Source dataset
uspto-grants-2002_09
Patent number
US06451805B1

Reaction notes

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