HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazole → 4,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-4-nitroso-pyrazole | HCID 12018212 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,5-Diamino-1-(2-fluorobenzyl)-3-(5-hydroxymethyl-2-furyl)-pyrazole | HCID 12018213 | — |
Reaction Steps
The compound from Example 5A (8 g) is dissolved in ethanol, treated with 0.5 g of 5% strength palladium on carbon and hydrogenated for 15 minutes in a Parr apparatus at a hydrogen pressure of 2 bar. The solution is filtered off with suction through kieselguhr and used for the next batch (Rf=0.21, T1E1, SiO2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06451805B1 |
| Source dataset | uspto-grants-2002_09 |
| ORD ID | ord-7b096c78b4aa484ea3da298ce5dd0031 |
| Source note | uspto-grants-2002_09 |