Phosphorus oxychloride → HCID 15391116, compound

HRID 1280436Notes

Reaction equation

HRID 1280436 reaction equation
[CH2:1]([N:8]1[C:12]2=[N:13][CH:14]=[N:15][C:16](O)=[C:11]2[C:10]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(C)C=CC=CC=1.C(OCC)(=O)C.O=P(Cl)(Cl)[Cl:38]>>[CH2:1]([N:8]1[C:12]2=[N:13][CH:14]=[N:15][C:16]([Cl:38])=[C:11]2[C:10]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 21584019Toluene ethylacetateHCID 178517907HCID 178517907, compound

Product 1

HCID 15391116HCID 15391116, compound

Procedure

6.6 g of 1-benzyl-3-(2-furyl)-4-hydroxypyrazolo[3,4-d]pyrimidine are boiled for 12 h in 100 ml of POCl3. The mixture is evaporated in vacuo, the residue is stirred with aqueous K2HPO4 solution and the mixture is extracted with ethyl acetate. After drying using Na2SO4 and concentrating in a rotary evaporator, 7.47 g of a solid are obtained which can be reacted directly for the next stage (Rf=0.8, SiO2, toluene/ethyl acetate=1:1).

Workup

  1. customThe mixture is evaporated in vacuo
  2. extractionthe mixture is extracted with ethyl acetate
  3. customAfter drying
  4. concentrationconcentrating in a rotary evaporator, 7.47 g of a solid
  5. customare obtained which

Sources & evidence

ORD record
ord-bc77d7ce9e4642af8d3f67eb05063ab7
Source dataset
uspto-grants-2002_09
Patent number
US06451805B1

Reaction notes

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