反应详情

Oxalyl chloride (4 mL) was added to a suspension of 4-[(2-pyrrolidinyl-1H-benzimidazol-1yl)methyl]benzoic acid (0.28 g, 0.872 mmol) in chloroform (50 mL). The mixture was heated at reflux for 1 hour and then concentrated under vacuum. The residue was diluted with toluene, concentrated under vacuum and then dried under vacuum at ambient temperature over the weekend to provide crude 4-[(2-pyrrolidinyl-1H-benzimidazol-1yl)methyl]benzoyl chloride.

1. temperatureThe mixture was heated
2. temperatureat reflux for 1 hour
3. concentrationconcentrated under vacuum
4. additionThe residue was diluted with toluene
5. concentrationconcentrated under vacuum
6. customdried under vacuum at ambient temperature over the weekend