Hydrochloric Acid → 4-(3-Nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine
Reaktionsgleichung
C([NH:5][C:6]([NH:8][CH:9]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1)[CH2:10]O)=[S:7])(C)(C)C.Cl>>[N+:18]([C:14]1[CH:13]=[C:12]([CH:9]2[CH2:10][S:7][C:6]([NH2:5])=[N:8]2)[CH:17]=[CH:16][CH:15]=1)([O-:20])=[O:19]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
The process is performed as in Example 2, starting with 1.49 g of N-(tert-butyl)-N′-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea in 14 cm3 of aqueous 6 N hydrochloric acid by heating to a temperature in the region of 100° C. for 2 h 30 min. By means of an identical work-up, 1.01 g of 4-(3-nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine are obtained in the form of a cream-colored solid melting at 232° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-37439abffcdb49cc8bd86461d450b729
- Quelldatensatz
- uspto-grants-2002_09
- Patentnummer
- US06451821B1
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