HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1280650Generated: October 26, 2026
Hydrochloric Acid → 4-(3-Nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine
https://huagongshe.com/reaction/1280650
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(tert-butyl)-N'-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea | HCID 22747831 | — |
| Product | 4-(3-Nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine | HCID 9964542 | 90.3% |
Reaction Steps
The process is performed as in Example 2, starting with 1.49 g of N-(tert-butyl)-N′-[2-hydroxy-1-(3-nitrophenyl)ethyl]thiourea in 14 cm3 of aqueous 6 N hydrochloric acid by heating to a temperature in the region of 100° C. for 2 h 30 min. By means of an identical work-up, 1.01 g of 4-(3-nitrophenyl)-4,5-dihydro-1,3-thiazol-2-ylamine are obtained in the form of a cream-colored solid melting at 232° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06451821B1 |
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| Source dataset | uspto-grants-2002_09 |
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| ORD ID | ord-37439abffcdb49cc8bd86461d450b729 |
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| Source note | uspto-grants-2002_09 |
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