(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid → (RS)-4-[1-(2-Indan-2-yl-ethyl)-pyrrolidine-3-sulfonyl]-phenol

HRID 1280708Notes

Reaction equation

HRID 1280708 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.[CH2:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:25][CH:24]1[CH2:32][CH2:33]OS(C1C=CC(C)=CC=1)(=O)=O>>[CH2:25]1[C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:23][CH:24]1[CH2:32][CH2:33][N:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1

Participants

3

Reactant 2

HCID 18425771(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acidHCID 86584021Toluene-4-sulfonic acid 2-indan-2-yl-ethyl ester

Product 1

HCID 18425794(RS)-4-[1-(2-Indan-2-yl-ethyl)-pyrrolidine-3-sulfonyl]-phenol

Procedure

The title compound, MS: m/e=372.3 (M+H+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and toluene-4-sulfonic acid 2-indan-2-yl-ethyl ester. Toluene-4-sulfonic acid 2-indan-2-yl-ethyl ester is a known compound and has been prepared as described in U.S. Pat. No. 3,984,407.

Sources & evidence

ORD record
ord-e7884884ed074d8f9460c0a98e311742
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

Loading…