(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid → (2RS,3SR)-2-{2-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-ethyl}-1,2,3,4-tetrahydro-naphthalen-2-ol

HRID 1280711Notes

Reaction equation

HRID 1280711 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.Br[CH2:24][CH2:25][C:26]1([OH:36])[CH2:35][CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27]1>>[OH:22][C:19]1[CH:20]=[CH:21][C:16]([S:13]([CH:10]2[CH2:11][CH2:12][N:8]([CH2:24][CH2:25][C:26]3([OH:36])[CH2:35][CH2:34][C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27]3)[CH2:9]2)(=[O:15])=[O:14])=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 18425771(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acidHCID 18425784(RS)-2-(2-bromo-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-ol

Product 1

HCID 18425788(2RS,3SR)-2-{2-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-ethyl}-1,2,3,4-tetrahydro-naphthalen-2-ol

Procedure

The title compound, MS: m/e=402.4 (M+H+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and (RS)-2-(2-bromo-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-ol.

Sources & evidence

ORD record
ord-bca09e4b14ea4d4da129eef6f473d4d7
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

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