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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1280711Generated: November 2, 2026

(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid → (2RS,3SR)-2-{2-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-ethyl}-1,2,3,4-tetrahydro-naphthalen-2-ol

https://huagongshe.com/reaction/1280711

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acidHCID 18425771—
Reactant(RS)-2-(2-bromo-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-olHCID 18425784—
Product(2RS,3SR)-2-{2-[3-(4-Hydroxy-benzenesulfonyl)-pyrrolidin-1-yl]-ethyl}-1,2,3,4-tetrahydro-naphthalen-2-olHCID 18425788—

Reaction Steps

The title compound, MS: m/e=402.4 (M+H+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and (RS)-2-(2-bromo-ethyl)-1,2,3,4-tetrahydro-naphthalen-2-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06451819B2
Source datasetuspto-grants-2002_09
ORD IDord-bca09e4b14ea4d4da129eef6f473d4d7
Source noteuspto-grants-2002_09