2-(2-chloro-ethyl)-2,3-dihydro-1H-isoindole → (RS)-4-{1-[2-(1,3-Dihydro-isoindol-2-yl)-ethyl]-pyrrolidine-3-sulfonyl)-phenol hydrochloride

HRID 1280713Notes

Reaction equation

HRID 1280713 reaction equation
FC(F)(F)C(O)=O.[NH:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1.[Cl:23][CH2:24][CH2:25][N:26]1[CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27]1>>[ClH:23].[CH2:34]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27][N:26]1[CH2:25][CH2:24][N:8]1[CH2:12][CH2:11][CH:10]([S:13]([C:16]2[CH:21]=[CH:20][C:19]([OH:22])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:9]1

Participants

3

Reactant 2

HCID 497752-(2-chloro-ethyl)-2,3-dihydro-1H-isoindoleHCID 18425771(RS)-4-(Pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid

Product 1

HCID 18425792(RS)-4-{1-[2-(1,3-Dihydro-isoindol-2-yl)-ethyl]-pyrrolidine-3-sulfonyl)-phenol hydrochloride

Procedure

The title compound, MS: m/e=373.3 (M+H+) was prepared from (RS)-4-(pyrrolidine-3-sulfonyl)-phenol trifluoroacetic acid salt and 2-(2-chloro-ethyl)-2,3-dihydro-1H-isoindole. 2-(2-Chloro-ethyl)-2,3-dihydro-1H-isoindole is a known compound and has been prepared as described in the following reference: G. Shoeb; J. Pharm. Sci.; 51; 1962; 469-471.

Sources & evidence

ORD record
ord-bcc6bc490d0549ecb1a6addb2c4cea91
Source dataset
uspto-grants-2002_09
Patent number
US06451819B2

Reaction notes

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