反应详情

(RS)-4-(Pyrrolidin-3-ylsulfanyl)-phenol hydrobromide (470 mg, 1.7 mmol), Et3N (0.35 ml, 2.5 mmol) and 1-phenyl-3-butan-2-one (0.25 g, 1.7 mmol) were suspended in CH2Cl2 (10 ml). After stirring overnight at room temperature, the reaction mixture was concentrated and chromatographed over silica gel (hexane-ethylacetate 1:1 then ethylacetate) to provide (RS)-4-[3-(4-hydroxy-phenylsulfanyl)-pyrrolidin-1-yl]-1-phenyl-butan-2-one (90 mg, 16%) as a brown oil, MS: m/e 342.2 (M+H+).

1. concentrationthe reaction mixture was concentrated
2. customchromatographed over silica gel (hexane-ethylacetate 1:1