反应详情

88.9 g (196 mmol) 2-[4-(1-diphenylmethylpiperidin-4-yl)-butyl]-isoindol-1,3-dione are suspended in 1000 ml ethanol and added to 22.0 g (440 mmol) hydrazine hydrate and heated to boiling for four hours. After cooling, the mixture is filtered and the solvent is removed under vacuum. The solid residue is distributed together with the filter residue under heat between 300 ml 10% sodium hydroxide solution and 300 ml acetic acid ethyl ester. The aqueous phase is extracted once again with 150 ml warm acetic acid ethyl ester. The combined organic phases are extracted twice, each with 300 ml 10% hydrochloric acid. The combined aqueous phases are adjusted to alkaline with 10% sodium hydroxide solution and extracted twice, each with 400 ml acetic acid ethyl ester. The combined organic phases are washed with 100 ml water and dried over sodium sulfate. The solvent is removed under vacuum, the residue is dried under high-vacuum and further processed without additional purification. Yield of gradually solidifying resin: 63 g (99%).

1. temperatureheated
2. temperatureAfter cooling
3. filtrationthe mixture is filtered
4. customthe solvent is removed under vacuum
5. temperatureunder heat between 300 ml 10% sodium hydroxide solution and 300 ml acetic acid ethyl ester
6. extractionThe aqueous phase is extracted once again with 150 ml
7. temperaturewarm acetic acid ethyl ester
8. extractionThe combined organic phases are extracted twice
9. extractionextracted twice
10. washThe combined organic phases are washed with 100 ml water
11. dry with materialdried over sodium sulfate
12. customThe solvent is removed under vacuum
13. customthe residue is dried under high-vacuum
14. customfurther processed without additional purification