Hydrazine hydrate (1:1) → HCID 12043826, compound

HRID 1280791Notes

Reaction equation

HRID 1280791 reaction equation
[CH3:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([CH:8]2[C:16](=O)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]2=O)=O)=[CH:4][CH:3]=1.O.[NH2:22][NH2:23]>>[C:2]1([CH3:1])[CH:20]=[CH:19][C:5]([C:6]2[C:8]3[CH2:16][C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[C:9]=3[NH:22][N:23]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 50314152-(4-methylbenzoyl)indan-1,3-dione

Product 1

HCID 12043826HCID 12043826, compound

Procedure

A mixture of 2-(4-methylbenzoyl)indan-1,3-dione (1.32 g, prepared in a similar manner to the starting material in Example 6) and hydrazine hydrate (15 ml) was boiled under reflux for 24 hours. The mixture was cooled, poured into ice-water and the solid was collected by filtration, washed with absolute ethanol and dried to give 3-(p-tolyl)-1,4-dihydroindeno[1,2-c]pyrazole, m.p. 267-269° C.

Workup

  1. temperatureunder reflux for 24 hours
  2. temperatureThe mixture was cooled
  3. filtrationthe solid was collected by filtration
  4. washwashed with absolute ethanol
  5. customdried

Sources & evidence

ORD record
ord-371d46c1a9ff4e9b9bdde1931abde206
Source dataset
uspto-grants-2002_09
Patent number
US06451834B1

Reaction notes

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