Hydrochloric Acid → 4-{3-[2-(3-Bromobenzoylamino)ethoxy]-7,12-dihydroxy-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-17-yl}pentanoic acid

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Reaction Steps

600 mg of methyl 4-{3-[2-(3-bromobenzoylamino)ethoxy]-7,12-dihydroxy-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-17-yl}pentanoate are dissolved in 19 ml of methanol and 4.6 ml of a 1N aqueous NaOH solution are added. The mixture is stirred at RT for 6 hours, then poured into 150 ml of a 2N aqueous HCl solution and extracted 4 times using 150 ml of MTB each time. The extract is dried over Na2SO4 and the solvent is removed in vacuo. 550 mg of a viscous oil are obtained, which are employed further as such.

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