HRID1280870

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID14798

Sodium Hydroxide

HNaO

结构：COC(=O)CCC(C)C1CCC2C3C(O)CC4CC(OCCNC(=O)c5cccc(Br)c5)CCC4(C)C3CC(O)C12C

HCID18425126

未命名化合物

PRODUCTS

生成物

结构：CC(CCC(=O)O)C1CCC2C3C(O)CC4CC(OCCNC(=O)c5cccc(Br)c5)CCC4(C)C3CC(O)C12C

HCID18425128

未命名化合物

收率 93.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

600 mg of methyl 4-{3-[2-(3-bromobenzoylamino)ethoxy]-7,12-dihydroxy-10,13-dimethylhexadecahydrocyclopenta[a]phenanthren-17-yl}pentanoate are dissolved in 19 ml of methanol and 4.6 ml of a 1N aqueous NaOH solution are added. The mixture is stirred at RT for 6 hours, then poured into 150 ml of a 2N aqueous HCl solution and extracted 4 times using 150 ml of MTB each time. The extract is dried over Na2SO4 and the solvent is removed in vacuo. 550 mg of a viscous oil are obtained, which are employed further as such.

WORKUP

后处理

extractionextracted 4 times
dry with materialThe extract is dried over Na2SO4
customthe solvent is removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-71eec1ada0954e84834435dd77eb2580
来源数据集: uspto-grants-2002_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06451781B1
来源说明: uspto-grants-2002_09

反应 SMILES

[Br:1][C:2]1[CH:3]=[C:4]([CH:40]=[CH:41][CH:42]=1)[C:5]([NH:7][CH2:8][CH2:9][O:10][CH:11]1[CH2:27][CH:26]2[C:14]([CH3:39])([CH:15]3[CH:23]([CH:24]([OH:28])[CH2:25]2)[CH:22]2[C:18]([CH3:37])([CH:19]([CH:29]([CH3:36])[CH2:30][CH2:31][C:32]([O:34]C)=[O:33])[CH2:20][CH2:21]2)[CH:17]([OH:38])[CH2:16]3)[CH2:13][CH2:12]1)=[O:6].[OH-].[Na+].Cl>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH:40]=[CH:41][CH:42]=1)[C:5]([NH:7][CH2:8][CH2:9][O:10][CH:11]1[CH2:27][CH:26]2[C:14]([CH3:39])([CH:15]3[CH:23]([CH:24]([OH:28])[CH2:25]2)[CH:22]2[C:18]([CH3:37])([CH:19]([CH:29]([CH3:36])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])[CH2:20][CH2:21]2)[CH:17]([OH:38])[CH2:16]3)[CH2:13][CH2:12]1)=[O:6]