反应详情

A mixture of (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine dihydrochloride (4.54 g, 16.0 mmol), 2 N NaOH solution (80 mL), and ethyl acetate (80 mL) was shaken, the organic layer was separated, and the aqueous layer was extracted with ethyl acetate (80 mL×2). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and evaporated to give free (R)-3-amino-1-(4-chlorobenzyl)pyrrolidine (3.35 g, 99%).

1. customthe organic layer was separated
2. extractionthe aqueous layer was extracted with ethyl acetate (80 mL×2)
3. dry with materialThe combined organic layers were dried over anhydrous sodium sulfate
4. filtrationfiltered
5. customevaporated